Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach
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چکیده
منابع مشابه
Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach
Although protein S (PROS1) and growth arrest-specific protein 6 (GAS6) proteins are homologous with a high degree of structural similarity, they are functionally different. The objectives of this study were to identify the evolutionary origins from which these functional differences arose. Bioinformatics methods were used to estimate the evolutionary divergence time and to detect the amino acid...
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Growth arrest-specific protein 6 (GAS6) shares a high degree of similarity with protein S (PS), a cofactor for the protein C (PC) anticoagulant pathway. PS consists of an N-terminal γ-carboxyglutamic acid (Gla) domain, a thrombin-sensitive region (TSR), four epidermal growth factor-like domains and a large C-terminal sex hormone-binding globulin-like domain. The TSR loop, which is not present i...
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ژورنال
عنوان ژورنال: Open Biology
سال: 2014
ISSN: 2046-2441
DOI: 10.1098/rsob.140121